|English: Doxepin Polski: Doxepin - Doksepina (Photo credit: Wikipedia)|
64% of patients chose to continue doxepin after study completion.
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From Oncology Times:
"Patients were asked to rate their pain at baseline and at 5, 15, 30, 60, 120, and 240 minutes later. The median pain score at baseline was 5.5 points, “which is the point at which it starts to interfere with eating and drinking,” he said.
During the four-hour period after the drug was administered, pain scores dropped an average of one point in the placebo group compared with two points for the doxepin group, a significant difference, he said. After the two-day period two-thirds of patients elected to continue doxepin."
“There are many, many local institutional recipes for mouth rinse and numbing rinses, so it is nice to see a controlled trial. However, the trial looks at only one single aspect of oral mucositis -- pain, and I would like to have seen swallowing and other endpoints evaluated as well.”
He also questioned how clinically meaningful “a transient improvement of one point on a 10-point pain scale really is to patients who are already on narcotics. Perhaps the same could be achieved by giving them one extra pill when they have breakthrough pain, rather than introduce an entire new class of drugs with its own set of side effects.”
The fact that patients on placebo improved one point on the pain scale could be just “a wonderful testament to the placebo effect,” Harari added.
The bottom line: Before the doxepin rinse is considered for widespread use, there should be a Phase III trial comparing the rinse with an extra narcotic capsule or with a numbing rinse, rather than placebo, he said."